School of Health Sciences: Recent submissions

  • Seasonal Variation of the Physicochemical and Bacteriological Quality of Water from Five Rural Catchment Areas of Lake Victoria Basin in Kenya 
    Ouma, SO; Ngeranwa, JN; Juma, KK; Mburu, DN (Journal of Environmental Analytical Chemistry, 2016)
    Seasonal and regional variation of the physicochemical and bacteriological characteristics of 180 water samples collected from five fish landing beaches of Luanda Rombo, Dunga, Marengo, Osieko and Usoma in the Lake ...
  • Effects of Maalox Plus® Antacid and PureCal® Calcium Supplements on Haematological and Biochemical Parameters of Rats Subjected to Alcohol Intoxication 
    Onyango, TO; Mburu, DN; Ngugi, MP; Kamau, JK; Juma, KK (Journal of a e Alcoholism & Drug Dependence, 2017-05-05)
    Habitual intake of alcohol is associated with health complications including depletion of the body’s stores of magnesium and calcium. In chronic alcoholism, treatment with magnesium and calcium has shown to normalize ...
  • Analgesic Potential of Acetone Leaf Extract of Caesalpinia volkensii Harms in Mice 
    Gitahi, SM; Mworia, JK; Juma, KK; Njagi, JM; Mwangi, BM; Aliyu, U; Njoroge, WA; Mwonjoria, KJ; Nyamai, DW; Ngugi, MP; Ngeranwa, JJN (Pharmaceutica Analytica Acta, 2021-09-08)
    Pain is defined as unpleasant feeling essential for body’s defense system. It acts as a warning signal against disturbances in the body. Conventional antinociceptives are expensive and have many side effects. Continued ...
  • Interdisciplinary Care Compliance with Antenatal Physical Activity and Exercises Guidelines for Management of Excessive Gestational Weight Gain for Prevention of Overweight and Obesity, Busia County, Kenya 
    Muia, C.M.; Eyinda, Milimo Johnstone; Okedi, William (African Journal of Empirical Research, 2025)
    Gestational overweight and obesity remains one of the leading causes of adverse health consequences for women and their offspring. Despite recommended antenatal guidelines on gestational weight gain monitoring and ...
  • Hemiplegic Patients - The Socio-Economic And Cultural Challenges At Coast Referral County Hospital 
    Eyinda, Johnstone Milimo (Research journali’s Journal of Public Health, 2018-08)
    Background: Hemiplegia is manifestation of muscles paralysis of the body contra-lateral to side of brain pathology. Patients tend to have a unique complex of physical, psychological and social problems. They experience ...
  • HIV diversity and drug resistance from plasma and non-plasma analytes in a large treatment programme in western Kenya 
    Kantor, Rami; DeLong, Allison; Balamane, Maya; Schreier, Leeann; Lloyd, Robert M; Injera, Wilfred; Kamle, Lydia; Mambo, Fidelis; Muyonga, Sarah; Katzenstein, David; Hogan, Joseph; Buziba, Nathan; Diero, Lameck (Journal of the International AIDS Society, 2014-11-18)
    Introduction: Antiretroviral resistance leads to treatment failure and resistance transmission. Resistance data in western Kenya are limited. Collection of non-plasma analytes may provide additional resistance information. ...
  • Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial 
    Mallewa, Jane; Szubert, Alexander J; Mugyenyi, Peter; Chidziva, Ennie; Thomason, Margaret J; Chepkorir, Priscilla; Abongomera, George; Baleeta, Keith; Etyang, Anthony; Warambwa, Colin; Melly, Betty; Mudzingwa, Shepherd; Kelly, Christine; Agutu, Clara; Wilkes, Helen; Nkomani, Sanele; Musiime, Victor; Lugemwa, Abbas; Pett, Sarah L; Dangarembizi, Mutsa Bwakura-; Prendergast, Andrew J; Gibb, Diana M; Walker, Sarah A.; Berkley, James A (The Lancet HIV, 2018)
    In sub-Saharan Africa, severely immunocompromised HIV-infected individuals have a high risk of mortality during the first few months after starting antiretroviral therapy (ART). We hypothesise that universally providing ...
  • Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations 
    . Martin, Alicia R; Atkinson, Elizabeth G.; Chapman, Sine´ad B.; Stevenson, Anne; Stroud, Rocky E.; Abebe, Tamrat; Akena, Dickens; Alemayehu, Melkam; Ashaba, Fred K.; Atwoli, Lukoye; Bowers, Tera; Chibnik, Lori B.; Daly, Mark J.; DeSmet, Timothy; Dodge, Sheila; Fekadu, Abebaw; Ferriera, Steven; Gelaye, Bizu; Gichuru, Stella; Injera, Wilfred E.; James, Roxanne; Kariuki, Symon M.; Kigen, Gabriel; Koenen, Karestan C.; Kwobah, Edith; Kyebuzibwa, Joseph; Majara, Lerato; Musinguzi, Henry; Mwema, Rehema M.; Neal, Benjamin M.; Newman, Carter P.; Newton, Charles R.J.C.; Pickrell, Joseph K.; Ramesar, Raj; Shiferaw, Welelta; Stein, Dan J.; Teferra, Solomon; Celia van der Merwe; Merwe, Celia van der; Zingela, Zukiswa; NeuroGAP-Psychosis Study Team (ALUPE UNIVERSITY, 2021-10-25)
    Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most ...
  • HIV Second-Line Failure and Drug Resistance at High- and Low Level Viremia in Western Ke 
    KANTOR, Rami; DELONG, Allison; SCHREIER, Leeann; REITSMA, Marissa; KEMBOI, Emanuel; ORIDO, Millicent; OBONGE, Salome; BOINETT, Robert; RONO, Mary; EMONYI, Wilfred; BROOKS, Katie; COETZER, Mia; BUZIBA, Nathan; Hogan, Joseph; DIERO, Lameck (HHS Pub lic Access, 2018-11-13)
    Objective: Characterize failure and resistance above and below guidelines-recommended 1,000 copies/mL virologic threshold, upon 2nd-line failure. Design: Cross-sectional study. Methods: Kenyan adults on lopinavir/r ...
  • Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa 
    Atkinson, Elizabeth G; Dalvie, Shareefa; Pichkar, Yakov; Kalungi, Allan; Majara, Lerato; Stevenson, Anne; Abebe, Tamrat; Akena, Dickens; Alemayehu, Melkam; Ashaba, Fred K; Atwoli, Lukoye; Baker, Mark; Chibnik, Lori B; Creanza, Nicole; Daly, Mark J; Fekadu, Abebaw; Gelaye, Bizu; Gichuru, Stella; Injera, Wilfred E; James, Roxanne; Kariuki, Symon M; Kigen, Gabriel; Koen, Nastassja; Koenen, Karestan C; Koenig, Zan; Kwobah, Edith; Kyebuzibwa, Joseph; Musinguzi, Henry; Mwema, Rehema M; Neale, Benjamin M; Newman, Carter P; Newton, Charles R.J.C; Ongeri, Linnet; Ramachandran, Sohini; Ramesar, Raj; Shiferaw, Welelta; Stein, Dan J; Stroud, Rocky E; Teferra, Solomon; Yohannes, Mary T; Zingela, Zukiswa; Martin, Alicia R (The American Journal of Human Genetics, 2022-09-01)
    African populations are the most diverseinthe world yetare sorelyunderrepresented inmedicalgeneticsresearch. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ...
  • Distribution Of Sickle Cell Trait in ABO/Rhesus Blood Types Among Voluntary Blood Donors in Bungoma County, Kenya 
    Thomas, Wekesa Khisa; Eric Omori Omwenga, Eric Omori; Emonyi, Wilfred Injera (Afr J Lab Haem Transf Sci, 2025-03)
    Background: Sickle cell trait is a haematological inherited disorder wide spread in several geographical regions. Individuals carrying sickle cell trait genes are asymptomatic and are eligible for blood donation; ...
  • Antiretroviral Treatment Interruptions Induced by the Kenyan Postelection Crisis Are Associated With Virological Failure 
    Mann, MPH Marita; Diero, MD Lameck; Kemboi, BSc Emmanuel; Mambo, MSc Fidelis; Rono, BSc Mary; Injera, PhD Wilfred; Delong, MSc Allison; Schreier, MSc Leeann; Kaloustian, MD Kara W.; Sidle, MD John; Buziba, MD Nathan; Kantor, MD Rami (National Institutes of Health Public Access, 2013-10-01)
    Background—Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited. Methods—We determined effects of unplanned TIs after the 2007–2008 Kenyan ...
  • Mosquitocidal Immune Response in BALB/c Mice Is Enhanced When Anopheles gambiae Mucin-1 cDNA Is Co-Administered with Interleukin-12 cDNA 
    Injera, Wilfred E.; Foy, Brian D.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Canadian Center of Science and Education, 2013)
    The midgut of the malaria - transmitting mosquito, Anopheles gambiae, can be targeted by vaccine-induced host immune factors that kill the mosquito after it ingests immunized host blood. The An. gambiae mucin 1 protein (AgMuc1) ...
  • Immunopathological Features Developing in the Mosquito Midgut after Feeding on Anopheles gambiae Mucin-1 / Interleukin-12 cDNA Immunized Mice 
    Injera, Wilfred E.; Kabiru, Elphantus W.; Gicheru, Michael M.; Githure, John I.; Beier, John C. (Universidad de La Frontera, 2013)
    The mosquito midgut is the organ into which the blood meal passes and in which, within a peritrophic membrane secreted by the epithelium, the blood is retained during digestion and absorption. The mosquito midgut is lined ...
  • Induction of Mosquitocidal Activity in Mice Immunized with Anopheles gambiae Midgut cDNA 
    Foy, B. D.; Magalhaes, T.; Injera, W. E.; Sutherland, I.; Devenport, M.; Thanawastien, A.; Ripley, D.; Ca´rdenas-Freytag, L.; Beier, J. C. (American Society for Microbiology, 2023-04)
    Vaccines that induce mosquito-killing (mosquitocidal) activity could substantially reduce the transmission of certain mosquito-borne diseases, especially vaccines against African malaria vectors, such as the mosquito ...
  • A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost effective manner 
    Boltz, Toni A; Chu, Benjamin B; Liao, Calwing; Sealock, Julia M; Ye, Robert; Majara, Lerato; Fu, Jack M; Service, Susan; Zhan, Lingyu; Medland, Sarah E; Chapman, Sinéad B; Rubinacci, Simone; DeFelice, Matthew; Grimsby, Jonna L; Abebe, Tamrat; Alemayehu, Melkam; Ashaba, Fred K; Atkinson, Elizabeth G; Bigdeli, Tim; Bradway, Amanda B; Brand, Harrison; Chibnik, Lori B; Fekadu, Abebaw; Gatzen, Michael; Gelaye, Bizu; Gichuru, Stella; Gildea, Marissa L; Hill, Toni C; Huang, Hailiang; Hubbard, Kalyn M; Injera, Wilfred E.; James, Roxanne; Joloba, Moses; Kachulis, Christopher; Kalmbach, Phillip R; Kamulegeya, Rogers; Kigen, Gabriel; Kim, Soyeon (2024-09-09)
    We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4x mean depth) and deep whole exome (30-40x mean depth) data in a single sequencing run. This technology ...
  • Use of Lot Quality Assurance Sampling to Ascertain Levels of Drug Resistant Tuberculosis in Western Kenya 
    Jezmir, Julia, Ted ,Matteo, Edwin, Bethany, Adrian, Lydia , Wilfred ,Jane Cohen, Zignol, Nyakan, Hedt-Gauthier, Gardner, Kamle, Injera, E. Carter, (jezmir, 2016-05-11)
    Objective: To classify the prevalence of multi-drug resistant tuberculosis (MDR-TB) in two different geographic settings in western Kenya using the Lot Quality Assurance Sampling (LQAS) methodology. Design: The ...
  • Cytokine’s Imbalance, the Hallmark of Immune Dysfunction in HIV/AIDS Patients in Rwanda 
    Ngangali, Jean Pierre; Mutesa, Leon; NSANZIMANA, Sabin; Munyemana, Jean Bosco; INJERA, Emonyi Wilfred; KIRTIKA, Patel; GATARE, Swaibu; Rutayisire, Robert; NDISHIMYE, Isabelle Valois; NTAGWABIRA, Edouard; Nkinda, Lilian; CHEMTAI, Alex k. (Research Square, 2021-07-30)
    Cytokines network drive Human Immunodeficiency Virus (HIV) inflammation and pathogenesis. Highly Active Antiretroviral Therapy (HAART) maintains low HIV viral load (VL) but chronic inflammation remains high in HIV subjects ...
  • Prevalence of Non-Tuberculosis Mycobacterium Pulmonary Disease in HIV-1 Patients with Presumptive Pulmonary Tuberculosis in Western Kenya 
    Ochayo, Anne; Wamalwa, Ronald; Barasa, Erick; Zablon, Jeremiah; Sowayo, George; Were, Tom; Gitonga, Godfrey; Shaviya, Nathan (Ethiopian Journal of Health Sciences, 2023-09-01)
    Background: Non-tuberculous mycobacteria (NTMs) are ubiquitous, free-living, environmental saprophytic microorganisms. NTMs belong to the genus Mycobacterium which includes Mycobacterium tuberculosis (MTB). NTMs have lately ...
  • The Occurrence of Alloantibodies among Multitransfused Oncology Patients at Moi Teaching and Referral Hospital 
    Wapukha, Zippy Bunoro; Emonyi, Wilfred Injera; Wanjau, Tabitha (International Journal of Recent Innovations in Medicine and Clinical Research, 2021-11-20)
    This study aimed at determining the presence and type of specific antibodies among multi transfused oncology patients, that causes alloimmunization, the ABO and Rhesus blood group that is most affected by alloimmunization ...

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